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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP4K5
All Species:
21.21
Human Site:
S728
Identified Species:
42.42
UniProt:
Q9Y4K4
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y4K4
NP_006566.2
846
95040
S728
A
G
S
Q
Q
L
D
S
I
H
V
T
Q
L
E
Chimpanzee
Pan troglodytes
XP_001155473
846
95023
S728
A
G
S
Q
Q
L
D
S
I
H
V
T
Q
L
E
Rhesus Macaque
Macaca mulatta
A4K2T0
487
55587
E375
M
V
I
N
T
E
D
E
E
E
E
G
T
M
K
Dog
Lupus familis
XP_851371
846
95039
S728
A
G
S
Q
Q
L
D
S
I
H
V
T
Q
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8BPM2
847
95026
S729
A
G
S
Q
Q
L
D
S
I
H
V
T
Q
L
E
Rat
Rattus norvegicus
Q924I2
873
98660
H757
T
P
Q
T
N
V
T
H
V
T
Q
L
E
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515144
898
100018
S780
S
G
S
Q
Q
L
D
S
I
H
V
T
Q
L
E
Chicken
Gallus gallus
Q5ZJK4
486
55318
E374
M
V
I
N
T
E
D
E
E
E
E
G
T
M
K
Frog
Xenopus laevis
Q6IP06
493
56486
M381
E
E
E
E
D
G
T
M
K
R
N
A
T
S
P
Zebra Danio
Brachydanio rerio
Q7ZUQ3
492
56062
S380
E
E
E
E
D
L
G
S
M
R
R
N
P
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8T0S6
669
75091
Q556
A
Y
P
L
M
N
E
Q
L
I
A
L
N
N
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23356
1096
122486
T975
A
Q
S
G
Q
T
T
T
P
H
C
I
V
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
25.2
98.1
N.A.
95.9
68.7
N.A.
87
24.5
25.4
25
N.A.
25.8
N.A.
23.8
N.A.
Protein Similarity:
100
99.7
39.8
99
N.A.
98.2
81.3
N.A.
90
39.7
40.3
40.5
N.A.
43.2
N.A.
41
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
0
N.A.
93.3
6.6
0
13.3
N.A.
6.6
N.A.
26.6
N.A.
P-Site Similarity:
100
100
20
100
N.A.
100
26.6
N.A.
100
20
6.6
26.6
N.A.
26.6
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
0
17
0
59
0
0
0
0
0
0
0
9
% D
% Glu:
17
17
17
17
0
17
9
17
17
17
17
0
9
0
42
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
42
0
9
0
9
9
0
0
0
0
17
0
0
0
% G
% His:
0
0
0
0
0
0
0
9
0
50
0
0
0
0
0
% H
% Ile:
0
0
17
0
0
0
0
0
42
9
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
17
% K
% Leu:
0
0
0
9
0
50
0
0
9
0
0
17
0
42
9
% L
% Met:
17
0
0
0
9
0
0
9
9
0
0
0
0
17
0
% M
% Asn:
0
0
0
17
9
9
0
0
0
0
9
9
9
9
0
% N
% Pro:
0
9
9
0
0
0
0
0
9
0
0
0
9
0
9
% P
% Gln:
0
9
9
42
50
0
0
9
0
0
9
0
42
0
9
% Q
% Arg:
0
0
0
0
0
0
0
0
0
17
9
0
0
9
0
% R
% Ser:
9
0
50
0
0
0
0
50
0
0
0
0
0
9
9
% S
% Thr:
9
0
0
9
17
9
25
9
0
9
0
42
25
9
0
% T
% Val:
0
17
0
0
0
9
0
0
9
0
42
0
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _